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What is Gene Expression?01:42

What is Gene Expression?

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Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...
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2026年的表达图谱:通过社区协作和整合,使公平和开放的表达数据成为可能.

Pedro Madrigal1, Anil S Thanki1, Silvie Fexova1

  • 1European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton CB10 1SD, United Kingdom.

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概括

表达图谱是一个全面的基因和蛋白质表达知识库. 它现在包括超过4500项研究,单细胞RNA-seq数据,以及新的分析工具,增强生物发现.

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科学领域:

  • 生物信息学是一种生物信息学.
  • 基因组学就是基因组学.
  • 蛋白质组学是指蛋白质组学.

背景情况:

  • 表达图谱是EMBL-EBI对基因和蛋白质表达数据的关键资源.
  • 它涵盖了多种物种,组织,细胞类型和疾病.

研究的目的:

  • 详细介绍Expression Atlas最近的扩展和增强的功能.
  • 突出新数据类型,分析模块和集成功能.

主要方法:

  • 来自67个物种的4500多项研究的数据整合.
  • 包括来自21个物种的数百个单细胞RNA-seq实验.
  • 开发一种新的标志性基因分析模块,用于大量基线实验.

主要成果:

  • 内容和功能大幅扩展.
  • 增加蛋白质组学覆盖范围和更新的基因型-组织表达 (GTEx) 概况.
  • 集成社区数据集和通过工作流更新增强可复制性.

结论:

  • 表达式图谱是一个显著增强的,公平的社区驱动的资源.
  • 它通过扩展数据和工具支持基础研究和翻译研究.
  • 未来的发展重点是现代化管道和AI-ready数据格式.