相关实验视频
Updated: Jan 9, 2026

10:41
Culture and Co-Culture of Mouse Ovaries and Ovarian Follicles
Published on: March 17, 2015
23.5K
文化媒体年龄不会影响试管婴儿的结果
Dean E Morbeck1,2, Natalie Hesketh1, Diana Bui1
1Genea Fertility, Sydney, NSW, Australia.
Human reproduction (Oxford, England)
|December 10, 2025
概括
单阶段胚胎培养基的年龄至其1年的保质期不会影响体外受精 (IVF) 的结果,包括胚胎发育,活产率或新生儿健康. 这一发现支持灵活的媒介使用,可能减少试管婴儿的浪费和成本.
科学领域:
- 生殖医学与神经病理学
- 胚胎学 胚胎学
- 在体外受精 (IVF)
背景情况:
- 媒介质量在试管婴儿中至关重要,组成,pH和度是关键因素.
- 胚胎培养中等保质期对试管婴儿成功率的影响仍未得到充分研究.
- 供应商之间不同的到期日期会造成物流挑战和潜在的浪费.
研究的目的:
- 调查单步胚胎培养基的储存时间是否会影响试管婴儿的结果.
- 评估中年龄与胚胎发育,怀孕率和出生体重之间的关联.
- 确定使用旧媒体在其保质期内是否会影响新生儿健康.
主要方法:
- 在澳大利亚八家诊所进行了9680次试管婴儿/ICSI周期的回顾性多中心研究 (2020年10月 - 2023年12月).
- 纳入标准:至少有一个受精卵子和已知的介质生产日期的自主循环.
- 使用回归模型分析胚胎发育,临床怀孕,活产,早产和出生体重.
主要成果:
- 媒体使用年龄在38至365天 (平均190天) 之间.
- 在中年和胚胎发育之间没有发现显著的关联 (第5/6天的胚芽细胞).
- 平均年龄与累积妊娠,活产,早产或出生体重结果没有相关性.
结论:
- 单步胚胎培养基的年龄在1年的保质期内,与不良的试管婴儿或新生儿结局无关.
- 研究结果支持在文化媒介的使用期限到期之前灵活使用,这可能会减少浪费和物流负担.
- 建议进行进一步的前性研究,以在不同媒体类型和环境中验证这些发现.
相关概念视频
In Vitro Fertilization
840
In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
840
Infertility in Females
3.6K
Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of...
Endometriosis, a condition characterized by abnormal growth of...
3.6K
Infertility in Males
509
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
509
Meiosis II
206.4K
Meiosis II is the second and final stage of meiosis. It relies on the haploid cells produced during meiosis I, each of which contain only 23 chromosomes—one from each homologous initial pair. Importantly, each chromosome in these cells is composed of two joined copies, and when these cells enter meiosis II, the goal is to separate such sister chromatids using the same microtubule-based network employed in other division processes. The result of meiosis II is two haploid cells, each...
206.4K
Oogenesis
68.8K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
68.8K

