在人类病原体Schistosoma mansoni中异常地继承了一种功能性基基同源
George R Wendt1, James J Collins1,2
1Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Science advances
|December 10, 2025
概括
体p53-1和循环素依赖性激酶抑制剂 (cki) 作为瘤抑制剂,控制膜的维持. 它们在Schistosoma mansoni中的联合淘汰会导致类似瘤的生长,揭示了对寄生虫平虫进化的洞察力.
科学领域:
- 寄生虫学的寄生虫学
- 分子生物学分子生物学
- 进化生物学 进化生物学
背景情况:
- 石体会导致石体病,这是一个被忽视的热带疾病.
- 瘤中膜的维持受p53-1的调节,p53-1是TP53瘤抑制剂的正方体.
- 仍然不完全理解p53-1在分裂体中的功能.
研究的目的:
- 鉴定了与p53-1.相关的schistosomecyclin-dependent激酶抑制剂同类物 (cki) 的作用.
- 调查cki和p53-1在Schistosoma mansoni的体膜维护和细胞增殖中的功能.
- 探索cki在寄生虫平虫中的进化起源.
主要方法:
- 在Schistosoma mansoni中,cki和p53-1的基因被淘汰.
- 击倒寄生虫的表型分析,重点关注体质完整性和细胞增殖.
- 在平虫物种及其自由生活的祖先中对cki同类的比较分析.
主要成果:
- 降低了CCI,导致了分裂细胞的过度增殖.
- 结合对cki和p53-1的抑制导致了类似瘤的瘤的形成.
- 在寄生虫平虫中存在cki同类物,但在它们的自由生活的亲属中不存在.
结论:
- cki 和 p53-1 在 Schistosoma mansoni 中作为瘤抑制剂起作用.
- 在寄生虫的进化过程中,cki基因可能是通过水平基因转移获得的.
- 这一发现表明,一种不寻常的基因遗传机制有助于寄生虫平虫的进化.
相关概念视频
01:33Pleiotropy
43.1K
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
43.1K
02:32Exon Recombination
4.0K
The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes.
Exon shuffling follows “splice frame rules.” Each exon...
Exon shuffling follows “splice frame rules.” Each exon...
4.0K
01:43Incomplete Dominance
29.6K
Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
29.6K
01:23Cystic Fibrosis: Pathogenesis
679
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
679
01:43Sex-linked Disorders
108.1K
Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
108.1K
01:35Pedigree Analysis
88.7K
Overview
88.7K