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接受辅助生殖的2型糖尿病患者的精液参数:回顾性分析

Gabriel Acácio de Moura¹, Mayara Lobato Lourenço², João Pedro Viana Rodrigues¹

¹Oswaldo Cruz Foundation (FIOCRUZ), Eusébio-CE, Brazil.

JBRA assisted reproduction

|December 10, 2025

概括

2型糖尿病 (T2DM) 在接受辅助生殖的男性中没有显著影响整体精液质量. 然而,高HbA1c水平与精子DNA碎片化增加有关.

科学领域:

生殖内分泌学生殖内分泌学
糖尿病学糖尿病学
安德罗学与人类学

背景情况:

2型糖尿病 (T2DM) 是一个日益严重的全球健康问题.
糖尿病会影响身体的各种功能,包括生殖健康.
了解它对男性生育能力的影响对于辅助生殖结果至关重要.

研究的目的:

研究在接受辅助生殖技术 (ART) 的患者中T2DM和精子参数之间的关联.
评估T2DM对精子度,形态,运动性和DNA碎片化的特定影响.

主要方法:

从2017年1月到2022年1月的医疗记录的回顾性分析.
包括患者的人口统计,糖尿病状况 (T1DM,T2DM,糖尿病前期) 和详细的精液参数.
统计分析以比较T2DM患者和对照组之间的精液参数,并评估与HbA1c的相关性.

主要成果:

在T2DM患者和正常对照者之间,在总体精液参数 (度,形态,运动性,pH,体积) 中没有发现显著差异.
作为连续变量分析的HbA1c显示与高精子DNA碎片化有显著的关联.
精子DNA碎片化被确定为T2DM管理可能受到影响的关键参数.

结论:

在接受ART的男性中,T2DM不是总体精液质量下降的主要决定因素.
升高的HbA1c水平,表明血糖控制,可能会对精子DNA完整性产生负面影响.
需要进一步的研究来探索针对性干预措施,以改善在接受ART的糖尿病患者中精子DNA碎片化的情况.

关键词:

生育能力生育能力生育能力生育能力男人的生育能力男人的生育能力代谢性疾病是代谢性疾病.生殖技巧生殖技巧精液分析精液分析第二种类型的糖尿病.

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