排卵触发了无助生殖,一个古老的问题仍然没有答案:一个系统的审查和元分析
Cristian Daniel Piccini1, Julia Andressa Tessari1, Murilo Gandon Brandão1
1Faculty of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
JBRA assisted reproduction
|December 10, 2025
概括
排卵触发剂,如hCG,在不孕症治疗中可能会增加排卵率,但不会显著改善妊娠结果. 需要更多的研究来证实它们对接受排卵诱导的女性的有效性和安全性.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 不孕症治疗 不孕症治疗
- 临床试验 临床试验
背景情况:
- 无法解释和无排卵不育影响了许多寻求辅助生殖技术的女性.
- 排卵诱导是一种常见的第一线治疗方法,通常涉及定时性交或子宫内授精 (IUI).
- 排卵触发器在提高成功率方面的作用仍然是研究的主题.
研究的目的:
- 评估排卵触发剂在改善怀孕和排卵率方面的有效性.
- 为了确定排卵是否会引发不孕症女性的并发症增加.
- 综合来自随机对照试验 (RCT) 关于排卵触发器使用的证据.
主要方法:
- 进行了对并行组RCT的系统审查和元分析.
- 研究包括了患有不明原因或无排卵性不孕症的妇女,她们通过自然性交或IUI进行排卵诱导.
- 分析的结果包括怀孕,排卵和并发症率;评估了偏差风险和证据确定性.
主要成果:
- 分析了6项涉及1218名女性的RCT,所有这些都使用人类胆管性腺激素 (hCG) 作为触发剂.
- 观察到排卵增加的趋势 (OR=1.70),但临床怀孕 (OR=1.23) 和活产 (OR=0.92) 率没有显著改善.
- 没有发现流产或多胎妊娠率的显著增加,跨研究偏差风险较低.
结论:
- 目前的证据不足以推或反驳在这个患者群体中使用排卵触发剂.
- 虽然hCG可能会增强排卵,但它对怀孕的影响仍然不确定.
- 需要进一步进行高质量的研究,以澄清排卵触发剂的益处和风险.
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