碳酸无水素IX可以预测胎儿生长限制在早期发病的先兆子?
1University of Health Sciences, Bursa Yuksek Ihtisas Training and Research Hospital, Department of Obstetrics and Gynecology - Bursa, Turkey.
概括
在早期孕前和胎儿生长受限时,碳酸无水酶IX水平升高. 较高的碳酸无水酶IX可能预测胎儿生长限制在孕前患者.
科学领域:
- 产科和妇科 产科和妇科
- 围产儿医学 围产儿医学
- 生物化学 生物化学
背景情况:
- 胎盘缺陷是孕前和胎儿生长限制 (FGR) 的关键因素.
- 它可以导致氧化应激,反应性氧物种的产生和缺氧.
- 碳酸无水酶IX (CA IX) 是一种低氧诱导性标记物.
研究的目的:
- 为了确定早期怀孕前的碳酸无水酶IX水平,有或没有FGR.
- 评价碳酸无水酶IX对FGR在早发性孕前的发展中的预测作用.
主要方法:
- 在180名参与者的前性研究中,有90人患有早期妊娠前症,90人为对照组.
- 孕前患者分组为有 (n=35) 和没有 (n=55) FGR的患者.
- 社会人口统计学,产科和实验室特征的比较,包括碳酸无水酶 IX.
主要成果:
- 中位碳酸无水酶IX在孕前和对照组中显著高 (p<0.001).
- 在患有FGR和没有FGR的孕前中,碳酸酶IX的中位数较高 (p=0.018).
- 碳酸无水酶IX>1.83 pg/mL预测FGR的敏感度为77.14%和特异性为52.73% (AUC=0.649).
结论:
- 碳酸无水酶IX可能表明在早期发病的孕前和FGR时有胎盘缺陷.
- 碳酸无水酶IX显示为FGR在早发性孕前的预测因子的潜力.
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