Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Hybridoma Technology01:31

Hybridoma Technology

17.1K
Hybridoma technology is used for the large-scale production of monoclonal antibodies. Monoclonal antibodies bind to only a single antigenic determinant or epitope. Such antibodies are used in research, diagnostics, and disease therapy. The hybridoma technology established in 1975 by Georges Köhler and Cesar Milstein was awarded the Nobel Prize in Medicine in 1984 for revolutionizing research and therapy.
Hybridoma Selection
Commonly used fusion techniques — electroporation,...
17.1K
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

15.8K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
15.8K
Humoral Immune Responses01:36

Humoral Immune Responses

83.2K
Overview
83.2K
Antibody Structure01:10

Antibody Structure

65.2K
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
65.2K
Antibody Structure and Classes01:25

Antibody Structure and Classes

8.1K
Antibodies, also known as immunoglobulins, are produced by B cells in response to foreign substances, such as bacteria and viruses. These proteins are critical for recognizing and neutralizing these substances, protecting the body from potential harm.
The basic structure of an antibody consists of four protein chains: two identical heavy chains and two identical light chains. These chains are held together by disulfide bonds and other non-covalent interactions, forming a Y-shaped structure.
8.1K
Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

1.3K
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
1.3K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Lactate-Mediated Epigenetic and Immunometabolic Reprogramming in Glioma: An Emerging Axis Linking Metabolism to Tumor Progression.

Biomedicines·2025
Same author

Detecting dynamical causality by intersection cardinal concavity.

Fundamental research·2025
Same author

Preoperative Physiological Reserve and Pathological Response as Independent Predictors of Survival in Esophageal Squamous Cell Carcinoma after Neoadjuvant Therapy.

Annals of surgical oncology·2025
Same author

The Prognostic Value of Nutritional and Immune Indices for Stage IB Non-Small Cell Lung Cancer Patients: Insights From a Retrospective Cohort Study.

Cancer medicine·2025
Same author

Surgical treatment of small-cell lung cancer: long-term prognosis and patterns of adjuvant therapy.

Translational lung cancer research·2025
Same author

Risk factors and clinical risk stratification of distant metastasis in early-stage lung cancer in never smokers.

World journal of surgical oncology·2025
Same journal

STED: flexible cross-modal topic modeling infers cell-type-specific regulatory landscapes from bulk epigenomics.

Briefings in bioinformatics·2026
Same journal

A knowledge-guided deep learning framework for quantitative nucleic acid testing.

Briefings in bioinformatics·2026
Same journal

Optimal transport for label transfer in single-cell multi-omics integration.

Briefings in bioinformatics·2026
Same journal

Continuous multi-omics pathway enrichment analysis resolves hidden functional heterogeneity.

Briefings in bioinformatics·2026
Same journal

Evaluating completeness, coherence, and consistency of genome-scale function annotations.

Briefings in bioinformatics·2026
Same journal

Transformers for single-cell RNA sequencing: a survey.

Briefings in bioinformatics·2026
查看所有相关文章

相关实验视频

Updated: Jan 9, 2026

Generation of Discriminative Human Monoclonal Antibodies from Rare Antigen-specific B Cells Circulating in Blood
13:14

Generation of Discriminative Human Monoclonal Antibodies from Rare Antigen-specific B Cells Circulating in Blood

Published on: February 6, 2018

10.9K

HuAbDiffusion:用于抗体人性化的离散语言扩散模型.

Dongping Liu1, Xiaohu Hao1, Long Fan1,2

  • 1Production and R&D Center I of LSS (Life Science Service), GenScript Biotech Corporation, No. 28, Yongxi Rd, Nanjing, Jiangsu 211100, China.

Briefings in bioinformatics
|December 10, 2025
PubMed
概括
此摘要是机器生成的。

HuAbDiffusion是一种新的扩散模型,从头开始产生人性化的抗体,保持或改善结合亲和力. 这种方法通过创造有效的人性化抗体,有助于治疗性抗体的开发.

关键词:
抗体是一种抗体.扩散模型的扩散模型.生成型模型的生成型模型.人性化的人性化.

更多相关视频

Laboratory Scale Production and Purification of a Therapeutic Antibody
09:54

Laboratory Scale Production and Purification of a Therapeutic Antibody

Published on: January 24, 2017

18.2K
Construction of Synthetic Phage Displayed Fab Library with Tailored Diversity
12:31

Construction of Synthetic Phage Displayed Fab Library with Tailored Diversity

Published on: May 1, 2018

14.6K

相关实验视频

Last Updated: Jan 9, 2026

Generation of Discriminative Human Monoclonal Antibodies from Rare Antigen-specific B Cells Circulating in Blood
13:14

Generation of Discriminative Human Monoclonal Antibodies from Rare Antigen-specific B Cells Circulating in Blood

Published on: February 6, 2018

10.9K
Laboratory Scale Production and Purification of a Therapeutic Antibody
09:54

Laboratory Scale Production and Purification of a Therapeutic Antibody

Published on: January 24, 2017

18.2K
Construction of Synthetic Phage Displayed Fab Library with Tailored Diversity
12:31

Construction of Synthetic Phage Displayed Fab Library with Tailored Diversity

Published on: May 1, 2018

14.6K

科学领域:

  • 生物技术是生物技术.
  • 免疫学 免疫学 免疫学
  • 计算生物学 计算生物学

背景情况:

  • 抗体人性化对于治疗性抗体开发至关重要.
  • 现有的抗体人性化方法面临局限性.

研究的目的:

  • 介绍HuAbDiffusion,这是一个离散的语言扩散模型,用于*de novo*抗体人性化.
  • 从三个互补的决定性区域 (CDR) 开始,为人性化抗体生成整个V区域序列.

主要方法:

  • 使用离散语言扩散模型 (HuAbDiffusion) 进行抗体人性化.
  • 基于提供的CDRs生成了整个V区域序列.
  • 评估了22个单克隆抗体 (mAbs) 的模型.

主要成果:

  • 与现有方法相比,HuAbDiffusion证明了有效性和优越性能.
  • 该模型成功地保持或增加了人性化抗体的结合亲和力.
  • 预先训练的语言模型有助于缩小最佳人性化抗体候选人的范围.

结论:

  • HuAbDiffusion是产生高亲和度人性化抗体的有希望的工具.
  • 该模型为治疗性抗体开发提供了一种高效的方法.
  • 开发的方法可以通过YabXnization服务器访问.