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黄斑 perfusion 密度和中部视野损失之间的关系在初级开放角度眼镜

Masayuki Inuzuka¹, Masato Matsuo¹, Masaomi Kubota¹

¹Department of Ophthalmology, Gifu University Graduate School of Medicine.

Journal of glaucoma

|December 10, 2025

概括

外鼻黄斑 perfusion 密度 (MPD) 的降低与初级开角玻璃眼 (POAG) 中视野敏感度的恶化有关. 这一发现突出了MPD.

科学领域:

眼科医生眼科眼科
医疗成像医学成像
玻璃眼研究研究玻璃眼研究

背景情况:

主要开角光眼 (POAG) 是不可逆转失明的主要原因.
评估青光眼的进展通常依赖于视野 (VF) 测试和结构光学连贯性断层扫描 (OCT) 测量.
需要补充成像生物标志物来监测疾病的进展,特别是在晚期.

研究的目的:

通过OCT血管造影 (OCTA) 测量的部门黄斑 perfusion 密度 (MPD) 和中央视野 (VF) 灵敏度 (汉弗里10-2) 之间的关系.
为了分析初级开角青光眼 (POAG) 的不同阶段之间的这种关系:轻度,中度和高级.

主要方法:

一个追溯的横截面研究涉及196只眼睛与POAG.
使用OCTA (6x6毫米表面) 量化了部门MPD.
MPD与汉弗雷10-2视野测试的总偏差 (TD) 的总和相关,并映射到相应的OCTA部门. 用30-2平均偏差 (MD) 来分类青光眼的严重程度.

主要成果:

外鼻MPD显示从轻度到严重的POAG (46.7%到39.6%) 的逐步下降.
外鼻MPD与中央10-2 TD总和显著相关 (r=0.364,P<1×10‒7) 并在中度 (r=0.298,P=0.013) 和严重 (r=0.286,P=0.022) 阶段内.
多变量分析表明,外鼻MPD (β=0.513,P<0.001) 和黄斑结节细胞内层 (mGCIPL) 厚度 (β=0.288,P<0.001) 独立地与10-2MD相关,而环皮状视网膜神经纤维层 (cpRNFL) 厚度则没有.

结论:

在所有严重程度的POAG中,减少外鼻MPD与中心功能视力损失密切相关.
外鼻MPD提供了对mGCIPL厚度的补充信息,用于监测玻璃眼.
对于评估青光眼的进展来说,OCTA是一个有价值的辅助工具,特别是当结构性OCT测量接近其极限时,包括在晚期疾病阶段.

关键词:

斑点血管 perfusion 密度斑点血管 perfusion 密度主要的开放角度光眼 (Glaucoma)细分分析细分分析视野缺陷视野缺陷视野缺陷

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