在健康的成年人中,对基于实验室的10%的CO2挑战的下丘脑-垂体-上腺 (HPA) 轴应激反应
Harrison Dickens1, L Riley Gournay-Berman1, Morgan Hill1
1University of Arkansas, Department of Psychological Science, 216 Memorial Hall, Fayetteville, AR 72701, United States.
Psychoneuroendocrinology
|December 10, 2025
概括
吸入二氧化碳 (CO2) 有效地触发了健康成年人的显著的神经内分泌,同情和情绪应激反应. 这个挑战方案显示了研究急性应激反应的潜力.
科学领域:
- 神经内分泌学神经内分泌学
- 心理生理学 心理生理学
- 压力研究 压力研究
背景情况:
- 急性压力反应与各种身体和心理障碍有关.
- 传统的实验室压力范式经常使用社会评估,可能限制压力因素的范围.
- 众所周知,二氧化碳 (CO2) 的吸入会引起恐慌症状,但其神经内分泌效应的理解较少.
研究的目的:
- 评估神经内分泌,同情和情绪反应,以10%的二氧化碳吸入挑战在健康的成年人.
- 研究二氧化碳吸入作为实验室压力因子的有效性,以引起可测量的生理和心理变化.
主要方法:
- 第二次分析检查了75名健康成年人的数据 (平均年龄为27.2岁,女性为53.3%).
- 参与者进行了为期5分钟的吸入10%的二氧化碳丰富空气.
- 测量了唾液皮质醇,心率和感知到的恐惧.
主要成果:
- 观察到二氧化碳挑战对唾液皮质醇有显著的线性和二次效应.
- 超过一半的参与者 (57.3%) 显示唾液皮质醇至少增加了50%.
- 与男性相比,女性和荷尔蒙避孕药使用者表现出较低的皮质醇反应,相比之下,男性和自然循环女性分别表现出较低的皮质醇反应.
- 心率和感知到的恐惧在任务期间显著增加.
结论:
- 二氧化碳吸入方案有效地引起了显著的神经内分泌,同情和情绪反应.
- 这种方法为研究实验室环境中的急性应激反应性提供了可行的工具.
- 研究结果强调了潜在的性别差异和荷尔蒙对应激反应的影响.
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