IL-35通过激活NRF2/GPX4通路来缓解巨细胞中的铁亡,以改善败血症诱导的ARDS

Panting Liu1, Chen Zhang1, Minkang Guo2

  • 1Department of Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China; The Chongqing Key Laboratory of Translational Medicine in Major Metabolic Disease, Chongqing, China.

Cytokine
|December 10, 2025
PubMed
概括

干白素-35 (IL-35) 通过减少巨细胞铁和炎症来缓解急性肺损伤 (ALI). IL-35促进M2巨细胞的两极分化,并保护肺上皮细胞免受亡.