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通过X射线介导的维生素D合成

Julia Kühn¹, Gabriele I Stangl¹

¹Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle-Wittenberg, Germany.

|December 10, 2025

概括

电离性X射线辐射可以将固醇前体转化为维生素D,为维生素D合成提供了一种新的方法. 这种意想不到的途径产生了大量的维生素D,相当于低剂量的紫外线B暴露.

科学领域:

生物化学生物化学
辐射化学辐射化学
营养科学营养科学

背景情况:

维生素D的合成主要与紫外线B (UVB) 光暴露有关.
像7-脱胆固醇和厄戈斯特醇这样的前体通过UVB辐射转化为维生素D2和维生素D3.

研究的目的:

调查电离性X射线辐射诱导其前体维生素D形成的潜力.
为了比较X射线照射与传统的UVB照射对维生素D合成的疗效.

主要方法:

结晶和溶于油中的7-脱水胆固醇和埃尔戈斯特被X射线照射,剂量为25kGy.
量化了维生素D的产量,并与在不同剂量 (20和200mJ/cm2) 的UVB照射中获得的产量进行了比较.
在复杂的矩阵中也评估了X射线辐射的影响,如,酵母和动物料.

主要成果:

在25kGy的X射线照射中,从晶体前体中产生了大量的维生素D3 (94μg/g) 和维生素D2 (74μg/g).
当前体在油中溶解时,X射线暴露产生了70 ng/g的维生素D3和45 ng/g的维生素D2.
来自X射线照射的维生素D产量与20mJ/cm2UVB的产量相当,尽管高剂量的UVB产量显著增加.

结论:

电离性X射线辐射代表了产生维生素D的新且未知的途径.
这一发现为维生素D的生产和强化开辟了新的途径,特别是在食品和料应用中.

关键词:

食品灭菌食品灭菌电离辐射辐射的电离辐射.紫外线是紫外线的光线.维生素D的合成方法这是X射线.

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