在炎症性肠道疾病中诱导和维持缓解的饮食的营养成分:从床边到盘子
L Godny1, T Pfeffer-Gik1, S Elial-Fatal1
1Division of Gastroenterology, Rabin Medical Center, Petah Tikva, Israel; Nutrition Department, Rabin Medical Center, Petah Tikva, Israel.
饮食疗法在炎症性肠道疾病 (IBD) 中表现有前途. 对于活跃的克罗恩病 (CD),特定的排除和肠道营养是关键. 对于性结肠炎 (UC),强调微生物调节,以灵活的饮食来维持缓解.
科学领域:
- 胃肠病学 胃肠病学
- 营养科学 营养科学
- 临床医学 临床医学
背景情况:
- 对治疗炎症性肠道疾病 (IBD) 的饮食疗法越来越感兴趣,包括克罗恩病 (CD) 和性结肠炎 (UC).
- 需要综合当前关于IBD评估饮食的营养成分和临床影响的证据.
- 治疗IBD需要了解饮食在疾病阶段和表型中的作用.
研究的目的:
- 审查和综合目前关于IBD饮食疗法的证据.
- 评估IBD饮食的营养成分和临床影响.
- 为不同的IBD阶段和表型提供有关饮食策略的见解.
主要方法:
- 关于IBD饮食干预的现有文献的叙述性综述.
- 对评估特定饮食成分和模式的研究进行分析.
- 对CD和UC的活跃疾病和缓解维护阶段的证据综合.
主要成果:
- 活性CD:排除饮食和肠道营养 (排他性肠道营养或CDED+PEN) 是有效的.
- 活性UC:饮食方法侧重于微生物代谢调节 (硫化物减少,SCFA增强).
- 缓解维护:数据有限,但像地中海 (MED) 这样的灵活,植物性,最小加工的饮食显示出潜力.
结论:
- 饮食策略在活跃的CD,活跃的UC和缓解维护之间有很大的差异.
- 对于活性CD的有效疗法包括排斥饮食和肠道营养.
- 对于UC和缓解,重点转向微生物调节和可持续的饮食模式;个性化咨询至关重要.
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