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Updated: Jan 9, 2026

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TCR-SUB1-DOCK2轴通过驱动致病性CD4+ T细胞组织透来促进自身免疫

Xiaoxue Li1, Wenhua Liang1, Weifang Wang1

  • 1Institute of Pediatric Infection, Immunity, and Critical Care Medicine, Shanghai Children's Hospital, Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Immunology and Microbiology, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Immunity
|December 10, 2025
PubMed
概括

转录因子SUB1控制T细胞在自身免疫性疾病中的迁移. 准TCR-SUB1-DOCK2通路为自身免疫性疾病提供了一个新的治疗策略.

关键词:
CD4 (((+) T 细胞 细胞在 DOCK2 里面,你会看到 DOCK2 的样子.在 SUB1 中, SUB1 是 SUB1, SUB1 是 SUB1.T细胞受体受体的 T 细胞受体.自身免疫性疾病 自身免疫性疾病细胞迁移 细胞迁移染色质可访问性 染色质可访问性细胞骨的重新安排.

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