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丝蛋白塑料用于持续和控制的药物释放

Kareen A Fajardo Cortes¹, Edward B Gordon¹, Mariah L Arral¹

¹4 Colby St, Department of Biomedical Engineering, Tufts University, Medford, MA 02155, United States.

International journal of pharmaceutics

|December 10, 2025

概括

这项研究使用热塑性成型制造制造了基于丝的药物输送系统. 这些水库提供可调节的,持续释放各种药物,包括敏感蛋白质,并显示出局部癌症治疗的希望.

科学领域:

生物材料科学生物材料科学
药物输送系统药物输送系统
材料工程材料工程材料工程

背景情况:

热机械加工使得丝可以在固态成型中变成可调节的生物材料.
基于丝的材料为控制药物释放的应用提供了潜力.

研究的目的:

使用热塑性成型开发嵌入酶,药物装载的丝储存器.
为了评估这些丝储存器的体外药物释放,降解和治疗疗效.
为了证明在热应力下丝矩阵内疗法的稳定性.

主要方法:

在不同温度 (95°C,125°C,145°C) 下进行丝热塑性成型.
封装蛋白质酶和治疗药物 (多克索鲁比,特莫索洛米德,L-阿斯巴拉金酶).
在70天内进行的体外药物释放和降解研究.
对U87质母细胞瘤细胞的细胞毒性测定.

主要成果:

处理温度影响了丝的结晶性,影响了药物释放率和降解.
嵌入式酶使可调节的,持续的药物释放成为可能.
封装药物保持了生物活性,并且表现优于无保护药物.
丝矩阵在热应力下稳定了基于小分子和蛋白质的治疗方法.

结论:

丝储提供了一个模块化平台,用于长期作用的药物输送,具有可调节的特性.
开发的系统为不稳定化合物提供结构性可调性,酶反应性和热稳定性.
这种方法对局部瘤治疗和其他持续药物输送应用有希望.

关键词:

降解降解是一种降解.药物释放释放药物释放药物释放药物嵌入酶嵌入酶的方法丝丝是什么意思丝丝热处理是一种热处理.

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