过度加工食品的摄入量高与大脑输液的改变,抑郁症状和炎症概况的增加有关
Adam Alvarez-Monell1, Sílvia Fernández-Barrès2, Carles Biarnés3
1Department of Psychiatry and Forensic Medicine, Universitat Autònoma de Barcelona, Bellaterra, Spain.
Journal of affective disorders
|December 10, 2025
概括
超加工食品 (UPF) 消费与抑郁症有关,可能是通过炎症和改变大脑输液,特别是在肥胖的人群中. 这项研究发现,UPF摄入会影响大脑输液和炎症标志物,小脑输液调解了抑郁症状的联系.
科学领域:
- 神经科学是一个神经科学.
- 营养精神病学 营养精神病学
- 免疫学 免疫学 免疫学
背景情况:
- 越来越多的证据将超加工食品 (UPF) 的消费与抑郁症联系在一起.
- 这种关联可能涉及炎症增加和大脑输液的改变.
- 肥胖作为伴随性疾病因素的作用需要调查.
研究的目的:
- 为了研究UPF消费,大脑输液和炎症之间的关联.
- 探索UPF消费与肥胖状况的相互作用.
- 检查大脑输液和炎症在UPF-抑郁症联系中的调解作用.
主要方法:
- 149名参与者被按肥胖状况 (BMI ≥30对<30) 和UPF消费 (类) 分类.
- 使用PHQ-9评估抑郁症状,通过IVIM MRI进行脑 perfusion,通过实验室测试评估白细胞计数.
- 统计分析包括t测试,ANOVA,回归和调解分析,控制肥胖状况.
主要成果:
- 摄入高UPF的肥胖个体在DACC,杏仁体和小脑中呈现出增加的输液.
- UPF消耗与淋巴细胞和单细胞计数呈正相关性.
- 小脑输液调解了UPF-抑郁链接,而淋巴细胞计数则调解了UPF对dACC输液的影响.
结论:
- 在关键的处理区域中,UPF的消耗与分数脑 perfusion 复杂相关.
- 增加脑输液可能是对内皮功能障碍的补偿反应.
- 与UPF相关的炎症,特别是涉及淋巴细胞,可能在观察到的关联中起作用.
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