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Updated: Jan 9, 2026

Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells
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六价通过SUV39H1增强翻译促进恶性转变

Yiwei Gu1, Yanan Cao2, Qing Ye2

  • 1Markey Cancer Center, University of Kentucky College of Medicine, Lexington, KY, 40506, USA; Department of Pharmacology and Nutritional Sciences, University of Kentucky College of Medicine, Lexington, KY, 40506, USA; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, China.

Chemico-biological interactions
|December 10, 2025
PubMed
概括

暴露于六价[Cr(VI]会通过mTORC1/4E-BP1信号激活上依赖翻译,从而促进癌症. 抑制这种途径通过减少SUV39H1转化来抑制Cr(VI) 诱导的细胞转化和DNA损伤.

关键词:
类似于癌症干细胞的特性在上限依赖的翻译.细胞的转化细胞的转化六价的六价是一种这是一辆SUV39H1.mTORC1/4E-BP1 信号传输系统

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