单细胞骨髓抑制细胞诱导的程度决定了在Mycobacterium avium感染期间宿主免疫反应

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Sisay Girma¹, Eva Leitzen², Andreas Beineke²

¹Institute for Microbiology, University of Veterinary Medicine Hannover, Hannover, Germany; College of Veterinary Medicine and Agriculture, Addis Ababa University, P.O. Box 34, Bishoftu, Ethiopia.

Microbes and infection

|December 10, 2025

概括

感染Mycobacterium avium的剂量会影响免疫细胞的反应. 较低剂量减少单细胞-MDSC诱导和保存T细胞,表明氧化水平影响细菌的持久性.

科学领域:

免疫学免疫学免疫学
微生物学微生物学

背景情况:

菌 (Mycobacterium avium,MAV) 是一种非结核性菌,具有越来越多的医学意义,但人们对其毒性知之甚少.
一种高度毒性的MAV菌株 (MAA25291) 在小鼠的免疫抑制单细胞 - 骨髓原抑制细胞 (M-MDSC) 中存活和复制,导致严重的疾病.
驱动MAA25291诱导和在M-MDSC中的持久性的机制仍然不清楚.

研究的目的:

为了研究M-MDSC在被MAA25291感染的小鼠中在高剂量 (临床疾病) 和低剂量 (亚临床疾病) 中的作用.
了解感染剂量如何影响M-MDSC诱导,免疫调节和细菌持久性.

主要方法:

在高剂量和低剂量中,小鼠被MAA25291感染.
使用流细胞计分析M-MDSC透.
组织病理学检查了脏和肝脏中的NOS2表达细胞和CD3+T细胞数量.

主要成果:

在两个感染组中都存在M-MDSC,但在低剂量感染后显著降低.
低剂量感染与脏和肝脏中减少的NOS2+细胞和更高的CD3+T细胞数量相关.
高剂量感染导致组织中显著的T细胞损失.

结论:

感染剂量严重影响M-MDSC诱导及其免疫调节功能.
在M-MDSC中MAA25291的诱导和持久性似乎取决于氧化 (NO) 生产水平.

关键词:

在MDSC中,MDSC是MDSC.在小鼠中感染病毒.在NOS2中,NOS2是NOS2.在T细胞,T细胞.这种细菌名为mycobacterium.

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