来自Polygala paniculata的寡糖 Ester与它们的NO抑制活性
Tran Hong Quang1, Pham Thi Cham1, Tran Thi Hong Hanh1
1Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Viet Nam.
Fitoterapia
|December 10, 2025
概括
分离了Polygala paniculata L.的化合物,并测试了它们的抗炎作用. 新的寡糖 (A-G) 显示出抑制巨细胞中氧化 (NO) 过度产生的潜力.
科学领域:
- 植物化学 植物化学
- 药理学 药理学是指药理学的学科.
- 免疫学 免疫学 免疫学
背景情况:
- 据报道,Polygala paniculata L. 具有各种不同的治疗性质.
- 传统医学使用P. paniculata治疗呼吸道和疼痛疾病.
- 寡糖 Ester 是一类具有潜在生物活性的化合物.
研究的目的:
- 从Polygala paniculata L.中分离和表征寡糖类.
- 评估分离化合物的抗炎性潜力,特别是它们对氧化 (NO) 生产的影响.
- 研究NO抑制的作用机制,包括iNOS相互作用.
主要方法:
- 使用多种色谱技术分离化合物.
- 通过综合光谱方法 (NMR,HRESI质谱) 阐明结构.
- 在实验室中对LPS刺激的RAW264.7巨中氧化 (NO) 抑制的评估.
- 分子对接模拟以预测与诱导性氧化合成酶 (iNOS) 的结合相互作用.
主要成果:
- 他们分离了10种寡糖,其中包括7种新化合物 (多聚帕尼科斯A-G).
- 1-6和8-9的化合物显著抑制了氧化 (NO) 的过度生产.
- 分子对接建议化合物1和4与iNOS活性部位结合,调节其活性.
- 化合物1和4也减弱了iNOS的表达,这表明它具有调节作用.
结论:
- 波利加拉 (Polygala paniculata L.) 是一种具有抗炎性质的新型寡糖 Ester 的来源.
- 隔离的化合物,特别是A-G多菌体,通过抑制NO的产生来调节炎症反应.
- 该机制涉及iNOS表达的下调,突出了炎症性疾病的治疗潜力.
相关概念视频
Oral Hypoglycemic Agents: α-Glucosidase Inhibitors
505
α-glucosidase inhibitors, including acarbose (Precose), miglitol (Glyset), and voglibose (Voglib) (primarily available in Asia), are drugs that control blood sugar levels by delaying the digestion of starch and disaccharides. They achieve this by inhibiting α-glucosidase enzymes in the intestine, which slow the absorption of carbohydrates in the intestine, which in turn leads to a prolonged release of the glucoregulatory hormone GLP-1 from intestinal L-cells.
Acarbose and miglitol are...
Acarbose and miglitol are...
505
Oligosaccharide Assembly
3.5K
Protein glycosylation starts in the ER lumen and continues in the Golgi apparatus. Glycosyltransferases catalyze the addition of sugar molecules or glycosylation of proteins. Usually, these enzymes add sugars to the hydroxyl groups of selected serine or threonine residues to form O-linked glycans or the amino groups of asparagine residues to form N-linked glycans. Different positions on the same polypeptide chain can contain differently linked glycans.
Multiple sugar molecules that may or may...
Multiple sugar molecules that may or may...
3.5K
Cellulose and Pectic Polysaccharides
4.5K
Every plant cell has a cell wall that protects the cell, provides structural support, and gives the cell shape. Cellulose, the main structural component of the plant cell wall, makes up over 30% of plant matter. It is the most abundant organic compound on earth. Cellulose is an unbranched polysaccharide composed of linear chains of glucose molecules linked by β (1→4) glycosidic bonds.
As a cell matures, its cell wall specializes according to its type. For example, the...
As a cell matures, its cell wall specializes according to its type. For example, the...
4.5K
Biosynthesis of Polysaccharides
521
Polysaccharides such as glycogen and starch are synthesized from nucleoside diphosphate sugars, primarily uridine diphosphate glucose (UDPG) and adenosine diphosphate glucose (ADPG). These activated glucose donors act as key intermediates in carbohydrate metabolism and biosynthesis. UDPG primarily involves glycogen synthesis in animals and many bacteria, while ADPG plays a fundamental role in starch synthesis in plants and certain bacteria.UDPG is formed when glucose-1-phosphate reacts with...
521
Indirect-Acting Cholinergic Agonists: Mechanism of Action
2.5K
Indirect-acting cholinergic agonists work by interacting with an enzyme called acetylcholinesterase (AChE) in the synaptic cleft. They can be reversible or irreversible inhibitors and have different effects on the enzyme.
Reversible inhibitors like edrophonium bind to a specific part of the enzyme called the anionic catalytic site. They form noncovalent bonds, which means they are not strongly attached to the enzyme. This creates a temporary and less stable enzyme–inhibitor complex,...
Reversible inhibitors like edrophonium bind to a specific part of the enzyme called the anionic catalytic site. They form noncovalent bonds, which means they are not strongly attached to the enzyme. This creates a temporary and less stable enzyme–inhibitor complex,...
2.5K
Indirect-Acting Cholinergic Agonists: Chemistry and Structure-Activity Relationship
884
Indirect-acting cholinergic agonists are agents that interact with the acetylcholinesterase enzyme in the synaptic cleft, preventing the breakdown of acetylcholine into choline and acetate. Consequently, the concentration of acetylcholine in the synaptic cleft increases. These agonists can be classified into reversible and irreversible inhibitors based on their duration of action.
Reversible inhibitors display short to medium durations of action. Short-acting agents include simple alcohols with...
Reversible inhibitors display short to medium durations of action. Short-acting agents include simple alcohols with...
884


