与非抗癌药物引起的药物相关的间歇性肺部疾病中定量计算机断层扫描值的变化
Junko Itano1, Hisao Higo2, Goro Kimura1
1Department of Allergy and Respiratory Medicine, National Hospital Organization Minami-Okayama Medical Center, Japan.
Internal medicine (Tokyo, Japan)
|December 10, 2025
概括
定量CT扫描显示,在诊断时与药物相关的间歇性肺病 (DILD) 中,肺部密度更高. 这些高衰减区域百分比 (HAA%) 在治疗后下降,与炎症标志物相关,有助于疾病监测.
科学领域:
- 肺部医学 肺部医学
- 放射学 放射学是一门学科.
- 医疗成像医学成像
背景情况:
- 间歇性肺病 (ILD) 的监测对于患者的治疗结果至关重要.
- 使用全肺密度 (WLD) 组图的定量计算断层扫描 (QCT) 提供了一种评估ILD的方法.
- 与药物相关的ILD (DILD) 需要特定的监测策略.
研究的目的:
- 在DILD患者中调查QCT指标的变化.
- 为了将QCT发现与炎症标志物相关联.
- 评估QCT在监测DILD中的实用性.
主要方法:
- 使用3D Slicer软件和WLD直方图进行QCT分析.
- 排除使用抗癌药物或活跃瘤的患者.
- 评估高衰减面积百分比 (HAA%) 在-700 HU,-600 HU,和-600至-250 HU.
主要成果:
- 与治疗后相比,诊断时的HAA%值显著更高 (所有指标的p<0.0002).
- 接受类固醇治疗的DILD患者的HAA%-600比未接受类固醇治疗的患者高 (p=0.0128).
- HAA%值与炎症标志物有显著的相关性.
结论:
- QCT衍生的HAA%值在DILD诊断时显著升高,并在治疗后降低.
- QCT指标与炎症标志物相关,这表明它们在评估DILD活动中的作用.
- QCT分析为监测DILD进展和治疗反应提供了有价值的工具.
更多相关视频
08:05Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia
Published on: December 19, 2020
14.7K
03:38Unilateral Lung Volume Analysis Using Micro-CT for Enhanced Assessment of Pulmonary Fibrosis in Preclinical Models
Published on: June 20, 2025
805
相关概念视频
01:13Radiological Investigation III: Pulmonary Angiogram and PET Scan
374
Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
374
01:20Imaging Studies for Cardiovascular System III: X-Ray
447
The most common cardiovascular diagnostic test is an X-ray. It produces images of the heart, blood vessels, and adjacent structures.
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
447
01:30Radiological Investigation II: MRI and Ventilation Perfusion Scan
485
Description
Magnetic Resonance Imaging (MRI) and Ventilation Perfusion Scans are two radiological investigations that offer detailed diagnostic images of the body, particularly lung structures.
MRI
MRI uses magnetic fields and radiofrequency signals to distinguish between normal and abnormal tissues. This technology provides a more detailed diagnostic image than CT scans, enabling it to characterize pulmonary nodules, stage bronchogenic carcinoma, and evaluate inflammatory activity in...
Magnetic Resonance Imaging (MRI) and Ventilation Perfusion Scans are two radiological investigations that offer detailed diagnostic images of the body, particularly lung structures.
MRI
MRI uses magnetic fields and radiofrequency signals to distinguish between normal and abnormal tissues. This technology provides a more detailed diagnostic image than CT scans, enabling it to characterize pulmonary nodules, stage bronchogenic carcinoma, and evaluate inflammatory activity in...
485