系统审查与阻塞性睡眠呼吸暂停相关的细胞外囊泡变化:对诊断和治疗的影响
Bárbara Santos1,2,3,4, Bárbara Ramalho1,2,5, Angela Relógio6
1CNC-UC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
概括
细胞外囊泡 (EVs) 通过影响炎症和心血管问题,与阻塞性睡眠呼吸暂停 (OSA) 有关. 研究强调电动汽车是OSA及其相关疾病的潜在生物标志物,尽管需要进一步描述.
科学领域:
- 心血管科学 心血管科学
- 在瘤学瘤学.
- 睡眠医学 睡眠医学
- 细胞生物学 细胞生物学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 是一个与心血管疾病和癌症相关的重大公共卫生问题.
- 细胞外囊泡 (EVs) 在细胞通信,氧化应激和炎症中至关重要,可能会影响OSA.
- 在OSA病理生理学中EVs的确切作用尚未完全理解.
研究的目的:
- 系统地审查目前关于阻塞性睡眠呼吸暂停 (OSA) 中细胞外囊泡 (EV) 的研究.
- 专注于电动汽车货物,表面蛋白质及其对氧化应激,炎症,癌症和心血管功能障碍的影响.
- 确定OSA及其并发症的潜在疾病机制和生物标志物.
主要方法:
- 对PubMed/Medline和Web of Science上的研究进行系统审查.
- 包括调查OSA和EVs的临床,动物和体外研究.
- 分析了600项独特的研究,其中27项符合纳入标准.
主要成果:
- 由OSA衍生的EVs影响内皮功能障碍,炎症和瘤细胞增殖.
- 转录和蛋白质组分析显示,OSA患者的EV中存在调节失调的microRNA和蛋白质.
- 在各种环境中,EV增强癌细胞迁移和内皮功能障碍.
结论:
- EVs在OSA病理生理学和相关的并发症中发挥着重要作用.
- 电动汽车作为OSA诊断和预后的最小侵入性生物标志物具有前景.
- 标准化的方法和全面的分析对于澄清电动汽车在OSA中的作用至关重要.
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