慢性肺部疾病的非小细胞肺癌中的检查点抑制性肺炎:使用全球联合数据库对ILD,COPD和普通人口进行比较研究
Geran Maule1,2, Mohammad Abuassi1,2, Samantha Sircar1,2
1University of Central Florida College of Medicine, University of Central Florida, Orlando, Florida, USA.
Respirology (Carlton, Vic.)
|December 10, 2025
概括
与COPD或无肺病患者相比,患有间歇性肺病 (ILD) 的患者面临更高的检查点抑制性肺炎 (CIP) 风险和更糟糕的结果,包括复发和死亡率.
科学领域:
- 在瘤学瘤学.
- 肺部病理学 肺部病理学
- 免疫学 免疫学 免疫学
背景情况:
- 检查点抑制性肺炎 (CIP) 是一种关键的免疫相关不良事件.
- 患有间歇性肺病 (ILD) 或慢性阻塞性肺病 (COPD) 的患者可能会增加CIP风险.
- 有限的数据比较CIP风险和ILD与COPD患者的结果.
研究的目的:
- 在接受免疫检查点抑制剂 (ICI) 的ILD,COPD和没有先前存在的肺病患者中比较CIP发生率,发病率,复发率和结局.
主要方法:
- 使用TriNetX研究网络进行的回顾性队列研究 (2017年1月至2023年1月).
- 接受ICI治疗的患者分为ILD,COPD和对照组.
- 倾向性得分匹配 (1:1:1) 用于调整基线特征;CIP通过ICD代码识别.
主要成果:
- 在ILD患者 (4.6%) 与COPD (1.9%) 和对照组 (1.5%) (p<0.001) 中,CIP发病率最高.
- 患有CIP的ILD患者出现了更高的复发率 (16.4%) 和全因住院治疗 (61%).
- 在ILD-CIP组中,所有原因的死亡率明显高 (41.1%).
结论:
- 潜在的间歇性肺部疾病大大提高了检查点抑制性肺炎的风险和严重程度.
- 研究结果强调需要加强对接受ICI治疗的ILD患者的监测和风险分层.
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