亚洲双抗血小板治疗得分的验证
Young-Hae Go1, Jeehoon Kang2,3, Junpil Yun2
1Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Korean circulation journal
|December 10, 2025
概括
亚洲-DAPT (ADAPT) 评分有效预测经皮冠状动脉干预 (PCI) 后接受双抗血小板治疗 (DAPT) 的患者的缺血和出血风险. 这种验证支持针对东亚人口的个性化DAPT策略.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
- 临床研究 临床研究
背景情况:
- 通过皮肤冠状动脉干预 (PCI) 后,双重抗血小板治疗 (DAPT) 是至关重要的.
- 建议对个体进行DAPT处方,以平衡缺血和出血风险.
- 亚洲特有的风险评分,就像亚洲-DAPT (ADAPT) 评分一样,是为了解决独特的人口特征而开发的.
研究的目的:
- 为了验证 ADAPT 对缺血和出血事件的评分的预测准确性.
- 评估缺血-ADAPT (I-ADAPT),出血-ADAPT (B-ADAPT) 和净-ADAPT得分在现实世界亚洲队列中的有用性.
- 确认这些分数在指导DAPT持续时间和强度时的适用性.
主要方法:
- 来自Korean PCI对R终点分析 (KOREAN-PCI) 多中心注册表的患者分析.
- 使用临床和血管学数据计算I-ADAPT,B-ADAPT和Net-ADAPT得分.
- 评估共同主终点:缺血性结局 (心血管死亡,心脏病发作,支架血栓形成) 和出血结局 (大/小出血).
主要成果:
- 这项研究包括4657名患者,平均随访时间为368天.
- 缺血和出血事件发生在0.9%的患者中.
- 无论是I-ADAPT和B-ADAPT得分,都显示出对各自的结果具有显著的预测价值 (C统计数据为0.672和0.715).
- 净ADAPT评分表明风险增加:缺血事件>0 (1.7倍),出血事件<0 (1.3倍).
结论:
- ADAPT评分被验证用于预测DAPT的东亚患者的缺血和出血风险.
- 这些分数为风险分层和个性化DAPT管理提供了宝贵的工具.
- 这些发现凸显了心血管药物治疗中对人群特异性风险评估的重要性.
相关概念视频
Coronary Artery Disease V: Interprofessional Care
203
Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
203
Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors
1.0K
Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
1.0K
Atherosclerosis III: Management
293
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
293
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
370
Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
370
Peripheral Artery Disease III: Interprofessional Care
221
Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
221
Angina IV: Management
215
IntroductionThe management of angina requires a comprehensive approach that includes pharmacological therapies, medical procedures, and lifestyle modifications.Pharmacological TherapiesAntiplatelet agents, such as aspirin, clopidogrel, prasugrel, and ticagrelor, play a pivotal role in preventing thrombus formation in patients with angina. These medications inhibit platelet aggregation and reduce the likelihood of myocardial infarction and other cardiovascular events.Anticoagulants, including...
215


