在长期治疗evolocumab期间,炎症生物标志物的性别差异
Federica Fogacci1, Serra İlayda Yerlitaş Taştan2, Marina Giovannini1
1Hypertension and Cardiovascular Risk Research Center, Medical and Surgical Sciences Department, Alma Mater Studiorum University of Bologna, Bologna, Italy (Drs Fogacci, Taştan, Giovannini Mitselman, Borghi, and Cicero).
Journal of clinical lipidology
|December 10, 2025
概括
长期的evolocumab治疗对男性和女性的炎症标志物有明显的影响. 炎症概况中的这些性别特异性反应凸显了个性化心血管风险管理策略的必要性.
科学领域:
- 心血管医学 心血管医学
- 免疫代谢过程中的免疫代谢.
- 药理学 药理学是指药理学的学科.
背景情况:
- 动脉样性心血管疾病 (ASCVD) 是一个全球领先的健康问题,与脂质代谢和炎症有关.
- 作为PCSK9抑制剂的Evolocumab有效降低LDL-C,但其对炎症生物标志物的长期影响和性别特异性的影响需要进一步研究.
研究的目的:
- 为了研究evolocumab对炎症标志物的长期影响.
- 为了确定这些炎症反应中的潜在的性别相关差异.
主要方法:
- 对202名高胆固醇血症患者 (111名男性,91名女性) 进行长度分析,接受了evolocumab治疗≥36个月.
- 评估单细胞与高密度脂蛋白胆固醇比率 (MHR) 和血小板与单细胞比率 (PMR),以及脂质参数.
- 探索炎症标志物,脂质水平和淋巴细胞计数之间的相关性,按性别分层.
主要成果:
- 男人始终显示出更高的MHR水平,而女性则显示出持续升高的PMR值.
- 在女性中发现了淋巴细胞计数和脂蛋白之间的显著逆相关性,但在男性中没有.
- 这些发现表明,对evolocumab治疗有明显的基于性别的免疫代谢反应.
结论:
- 在长期治疗evolocumab的炎症反应中存在明显的生物学性别差异.
- 性别特定的监测和个性化策略对于心血管风险管理至关重要.
- 需要进一步的研究,以了解这些炎症变化的临床影响,降脂治疗的结果.
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