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Updated: Jan 9, 2026

Visualization of Endogenous Mitophagy Complexes In Situ in Human Pancreatic Beta Cells Utilizing Proximity Ligation Assay
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Visualization of Endogenous Mitophagy Complexes In Situ in Human Pancreatic Beta Cells Utilizing Proximity Ligation Assay

Published on: May 2, 2019

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在ERMCS中,GLP-1R与VAPB和SPHKAP结合,调节β细胞线粒体重塑和功能

Gregory Austin1, Affiong I Oqua1, Liliane El Eid1

  • 1Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology, and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.

Nature communications
|December 10, 2025
PubMed
概括

类似葡萄糖-1受体激活剂改善线粒体健康和胰腺β细胞功能. 这项研究揭示了一种新的信号通路,将受体激活与线粒体适应联系起来,这对于预防2型糖尿病至关重要.

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Mixed Primary Cultures of Murine Small Intestine Intended for the Study of Gut Hormone Secretion and Live Cell Imaging of Enteroendocrine Cells09:16

Mixed Primary Cultures of Murine Small Intestine Intended for the Study of Gut Hormone Secretion and Live Cell Imaging of Enteroendocrine Cells

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The pancreatic islets comprising only 1%-2% of the volume are highly vascularized and innervated mini-organs. They contain five endocrine cell types, including β cells that secrete insulin, which is synthesized as a single polypeptide chain, preproinsulin, processed to proinsulin, and finally to insulin and C-peptide. This process is complex and regulated, involving the Golgi complex, the endoplasmic reticulum, and the secretory granules of the β cell.
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