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Updated: Jan 9, 2026

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这种PIK3CA/AKT通路驱动了rhabdomyosarcoma中治疗阻力

Qiqi Yang1,2,3,4, Yueyang Wang1,2,3, Luis A Corchete Sanchez2

  • 1Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA, USA.

Nature communications
|December 10, 2025
PubMed
概括

奥拉巴里布和泰莫索洛米德 (OT) 治疗对狂宫肌肉瘤 (RMS) 有希望,但出现了耐药性. 用alpelisib准PIK3CA/AKT通路可以克服这种抵抗,为难以治疗的RMS提供了一种新策略.

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