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Updated: Jan 9, 2026

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对两种免疫主导的SARS-CoV-2核囊表观体的T细胞识别中的克隆限制和多样性的结构洞察

Ping Yuan1, Guodong Chen1, Yukun Li2

  • 1Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.

Nature communications
|December 10, 2025
PubMed
概括

对SARS-CoV-2核体蛋白表位LLL和SPR的T细胞反应在结构上有所不同. 了解这些差异可以为冠状病毒疫苗设计和T细胞识别的计算建模提供信息.

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
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