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Updated: Jan 9, 2026

In-vitro Reconstitution of Bacterial Ubiquitination and VCP/p97-mediated Elimination
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Published on: January 2, 2026

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对于TLR3的贩运和其先天的免疫信号传递来说,HRD1的ubiquitination是至关重要的

Lianfeng Zhao1,2, Zinan He1,2, Yao Sun1,2

  • 1Zhejiang Provincial Key Laboratory of Pancreatic Disease, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.

Nature communications
|December 10, 2025
PubMed
概括

E3结合酶HRD1 (HMG-CoA还原酶降解蛋白1) 对于托尔类受体3 (TLR3) 的贩运和激活至关重要. 缺少HRD1会通过阻断受体的运输和处理来损害TLR3的信号传递,从而影响先天免疫反应.

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