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Updated: Jan 9, 2026

Exogenous Administration of Microsomes-associated Alpha-synuclein Aggregates to Primary Neurons As a Powerful Cell Model of Fibrils Formation
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MSAα-synuclein聚合物的种子放大保留了来自大脑的聚合物的生物和结构性质

Fei Wang1, Victor Banerjee1, Carla Barria1

  • 1Mitchell Center for Alzheimer's Disease and Related Brain Disorders, Department of Neurology, University of Texas McGovern Medical School at Houston, Houston, TX, USA.

Nature communications
|December 10, 2025
PubMed
概括

阿尔法-合成核素种子放大试验 (αSyn-SAA) 成功地放大了多重系统缩 (MSA) 大脑中的错误折叠的阿尔法-合成核素 (αSyn) 菌株. 放大的αSyn纤维保持疾病特异性,模仿MSA病理在体外和体内.

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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