相关实验视频

Updated: May 1, 2026

Measurement of Basal and Forskolin-stimulated Lipolysis in Inguinal Adipose Fat Pads

Measurement of Basal and Forskolin-stimulated Lipolysis in Inguinal Adipose Fat Pads

Published on: July 21, 2017

亚素抑制脂肪细胞脂解会损害体内温度调节

Inka Rapöhn¹, Helen Broghammer¹, Anne Hoffmann¹

¹Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany.

Nature communications

|December 10, 2025

概括

瓦斯是一种新发现的棕色脂肪组织 (BAT) 激素,它调节能量消耗. 这项研究揭示了Vaspin.

科学领域:

内分泌学在内分泌学.
代谢性疾病研究研究.
脂肪组织生物学脂肪组织生物学

背景情况:

棕色脂肪组织 (BAT) 功能障碍与肥胖,胰岛素抵抗和心血管问题有关.
随着BAT的分泌,分泌出一种叫做托卡因的荷尔蒙,可以控制热生成.
了解巴托卡因对于代谢健康研究至关重要.

研究的目的:

为了确定参与温度调节的新型巴托金.
为了研究蛇形的作用作为一个调节的 batokine.
阐明瓦斯影响脂肪细胞功能和能量平衡的机制.

主要方法:

使用脂肪细胞特异性过度表达小鼠模型研究了瓦斯的功能.
研究了瓦斯在暴露在寒冷和禁食期间对BAT激活和温度调节的影响.
使用生物化学分析来确定瓦斯的结合标 (LRP1,LDLR,vLDLR) 和下游信号通路.
在人类脂肪组织和体外研究中进行了基因组丰富分析.

主要成果:

瓦斯被确定为一种新型巴托金,它抑制了BAT激活,并损害了温度调节.
瓦斯与LDL受体 (LRP1,LDLR,vLDLR) 结合,抑制脂肪细胞中的上腺体信号传递和脂解.
瓦斯调节固酶活性和内细胞脂质的吸收.
人类研究证实了瓦斯的抗脂解作用,表明功能得到保护.

结论:

瓦斯作为BAT热能活动的关键调节器.
通过限制过度的能量消耗,瓦斯宾有助于保持代谢平衡.
瓦斯宾代表了肥胖等代谢障碍的潜在治疗标.

更多相关视频

Measuring the Rate of Lipolysis in Ex Vivo Murine Adipose Tissue and Primary Preadipocytes Differentiated In Vitro

Measuring the Rate of Lipolysis in Ex Vivo Murine Adipose Tissue and Primary Preadipocytes Differentiated In Vitro

Published on: March 17, 2023

Author Spotlight: Illuminating New Avenues for Adipose Tissue Metabolism and Disease Prevention

Author Spotlight: Illuminating New Avenues for Adipose Tissue Metabolism and Disease Prevention

Published on: October 6, 2023

相关概念视频

Inflammation

Inflammation

Regulation of Metabolism

Regulation of Metabolism

Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...

Overview of Lipid Metabolism

Overview of Lipid Metabolism

Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...

Cholesterol: Significance and Regulation

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...

Thermoregulation

Thermoregulation

The human body has a sophisticated thermoregulation system that employs negative feedback mechanisms to maintain an optimal core temperature. When the core temperature drops, peripheral and central thermoreceptors send signals to the hypothalamus, activating the heat-promoting center. This center triggers several responses aimed at increasing the core temperature. First, vasoconstriction reduces the flow of warm blood from internal organs to the skin so that the heat is not lost from the skin,...