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与传统的剂量率辐射相比,碳离子FLASH辐射减少了急性皮肤毒性

Yukari Yoshida¹, Hiromu Suda², Mutsumi Tashiro²

¹Gunma University Heavy Ion Medical Center, 3-39-22, Showa-machi, Maebashi, 371-8511, Gunma, Japan. yyukari@gunma-u.ac.jp.

Scientific reports

|December 10, 2025

概括

超高剂量率FLASH放射疗法使用碳离子节省正常组织. 碳离子FLASH辐射需要比常规剂量高1.5倍的剂量来达到类似的生物效应,显示出显著的正常组织节约.

科学领域:

辐射瘤学辐射瘤学
生物物理学的生物物理.
临床前研究临床前研究

背景情况:

闪光辐射疗法利用超高剂量率 (>40 Gy/s) 进行潜在的治疗窗口增强.
证明正常组织节省了电子,光子和质子,但对重离子存在有限的数据.
碳离子为放射治疗提供独特的物理和生物特性.

研究的目的:

研究碳离子FLASH辐射对正常组织的生物学影响.
评估在常规剂量和FLASH剂量率下碳离子辐射后小鼠的急性皮肤反应.
量化评估碳离子FLASH疗法的正常组织节约潜力.

主要方法:

C3H/He小鼠接受了碳离子笔束扫描辐射到后肢.
剂量在入口区域范围为34-58 Gy (LET: 13 keV/μm).
用常规 (CONV:~0.05 Gy/s) 或FLASH (~180 Gy/s) 剂量速率进行辐射.
对急性皮肤反应进行了长达5周的监测.

主要成果:

皮肤反应的时间模式在CONV和FLASH组之间是相似的.
在所有剂量和时间点上,FLASH组始终显示较低的皮肤反应得分.
剂量反应比较显示,碳离子FLASH辐射具有显著的组织节约效应.
用FLASH需要大约1.5倍的剂量才能产生与CONV.相同的生物效应.

结论:

碳离子FLASH辐射显示出显著的正常组织节约潜力.
通过在临床前模型中的剂量反应比较,FLASH效应得到了定量证实.
这些发现支持进一步研究碳离子FLASH放射治疗的临床应用.

关键词:

碳离子束是碳离子束.一个闪光灯.辐射辐射辐射辐射辐射辐射辐射皮肤皮肤皮肤皮肤超高剂量速度的超高剂量速度.

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