在癌症护理连续过程中进行液体活检
Blair V Landon1, Akshaya V Annapragada1, Noushin Niknafs1
1The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Nature medicine
|December 10, 2025
概括
使用无细胞DNA (cfDNA) 的液体活检显示出癌症检测和监测的前景. 需要进一步的研究来提高敏感性和可访问性,以便在瘤学中广泛的临床使用.
科学领域:
- 在瘤学瘤学.
- 分子诊断学 分子诊断
- 基因组学就是基因组学.
背景情况:
- 液体活检为癌症检测,表征和监测提供了一种最少的侵入性方法.
- 循环无细胞DNA (cfDNA) 分析是液体活检的关键技术,从向测序演变为全基因组和表观基因组方法.
- 人工智能越来越多地用于分析cfDNA,用于更广泛的癌症相关变化.
研究的目的:
- 审查目前在液体活检中检测cfDNA的技术和分析方法.
- 讨论这些方法在精密瘤学的临床有效性和实用性.
- 确定在癌症护理连续过程中实施液体活检的挑战和机会.
主要方法:
- 对cfDNA分析现有技术的审查,包括向测序,全基因组测序和表观基因组测序.
- 讨论分析方法,包括人工智能的作用.
- 对液体活检应用的临床有效性和实用性数据的评估.
主要成果:
- 在cfDNA分析的进步已经扩大了可检测变化的范围.
- 仍然存在重大技术和临床挑战,包括实现临床上有意义的检测灵敏度和测试可访问性.
- 对循环瘤DNA负担的前性评估对于治疗决策至关重要.
结论:
- 液体活检对精确瘤学具有变革性的潜力.
- 解决敏感性,可访问性和临床验证方面的挑战对于广泛采用至关重要.
- 在癌症治疗连续的进一步实施需要持续的技术和分析发展.
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