在IgA神经病变中,高血糖蛋白血症的预后价值
Di Wu1, Yingxin Rong1, Xinyue Wang1
1National Clinical Research Center for Kidney Diseases, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, 305 East Zhongshan Road, Nanjing, 210016, China.
超同胞血症 (HHcy) 与IgA脏病 (IgAN) 患者的较差功能和更严重的病理有关. 这种情况独立地预测功能衰竭,突出其在IGAN进展中的重要性.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内部医学 内部医学
- 临床研究 临床研究
背景情况:
- 过高homocysteinemia (HHcy) 在慢性病 (CKD) 中很常见.
- IgA 脏病 (IgAN) 患者,特别是在早期的CKD 阶段,经常表现出 HHcy.
研究的目的:
- 在被诊断为IGAN的患者中调查HHcy和结局之间的关联.
- 确定HHcy是否是IGAN中末期病 (ESKD) 的独立风险因素.
主要方法:
- 评估了366名经过活检证明的Igan患者,将他们分为HHcy和正常Hcy组.
- 评估临床和病理特征,包括eGFR,蛋白尿和组织学.
- 利用多变量Cox回归和Kaplan-Meier分析来评估ESKD风险和存率.
主要成果:
- 患有HHcy的患者表现出明显恶化的功能和更严重的组织病理发现.
- HHcy与较高的蛋白尿,血球硬化,新月病变和管道损伤率有关.
- HHcy独立预测ESKD (HR=4.008,P=0.036),在HHcy组中观察到的性存活率明显较差 (P<0.001).
结论:
- 超homocysteinemia与功能下降和IgAN中先进的病理变化有关.
- 在IgA脏病患者中,HHcy是功能衰竭 (ESKD) 的独立风险因素.
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