血液中的血栓前分析物和血小板激活与COVID-19的急性后续症状有关
Luke A Whitcomb1, Kailey Berry2, Stephanie M LaVergne3
1Medical Scientist Training Program, Oregon Health & Science University, Portland, OR, United States.
BMC infectious diseases
|December 10, 2025
概括
早期识别长期COVID生物标志物至关重要. 这项研究发现了独特的免疫和血管特征,包括高凝血因子,在感染后持续很长时间,有助于风险分层和治疗开发.
科学领域:
- 免疫学 免疫学 免疫学
- 血管生物学 血管生物学
- 蛋白质组学是指蛋白质组学.
背景情况:
- 后急性COVID-19 (PASC) 或长期COVID,涉及SARS-CoV-2感染后持续的症状.
- 鉴定PASC的预测生物标志物对于预后和治疗开发至关重要,但仍然具有挑战性.
研究的目的:
- 进行血液样本的纵向,多omics分析,以确定可预测PASC的免疫和血管特征.
- 确定与PASC发展和持久性相关的早期循环生物标志物.
主要方法:
- 从75名COVID-19患者的血液样本进行纵向分析,按疾病严重程度和PASC状态分层.
- 集成有针对性的多重检测,非有针对性的蛋白质组学 (LC-MS) 和全血流细胞计.
- 路径丰富分析以确定与PASC相关的生物过程.
主要成果:
- 发展PASC的个体表现出明显的早期 (感染后1-35天) 标志,包括血因子-IX,组织因子和tPA的升高,表明免疫血栓形成.
- 持续的中性粒细胞脱粒化,血小板激活和细胞外矩阵重塑持续超过症状出现后的77天.
- 通过整合的蛋白质和细胞数据,通过PASC特有的持久免疫血管特征被确定.
结论:
- 慢性免疫和内皮功能障碍在长期COVID病变发生过程中发挥着关键作用.
- 已识别的生物标志物可能有助于PASC.早期风险分层.
- 这些发现支持对长期COVID幸存者的精确诊断和有针对性的干预措施的开发.
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