一项关于在放射治疗患者中优化膀体积一致性的策略的研究
Shunan Guo1, Haitao Lin1, Ying Chen2
1Department of Radiation Oncology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, 1111 XianXia Road, Shanghai, 200336, China.
European journal of medical research
|December 10, 2025
概括
优化放射治疗工作流程显著改善了癌症患者的膀体积的一致性. 这导致形光束CT和便携式扫描仪测量之间的差异减少,提高了治疗的准确性.
科学领域:
- 辐射疗法 辐射疗法
- 医学物理 医学物理
- 在瘤学瘤学.
背景情况:
- 精确的膀体积测量对于精确的骨盆放射治疗至关重要.
- 膀体积的变化可能导致低于最佳的辐射向和毒性增加.
- 现有的工作流程可能无法始终实现目标膀体积.
研究的目的:
- 评估多步骤工作流程优化在改善膀体积的一致性方面的有效性.
- 评估优化对形光束CT (VCBCT) 和便携式扫描仪 (VHD5) 测量之间的协议的影响.
- 为了量化绝对膀体积差异变化 (腹膜VCBCT-VHD5腹膜) 在优化后.
主要方法:
- 用一种简单的随机抽样方法来选择工作流优化前后的患者.
- 分析了两组患者 (前列腺癌,宫癌,直肠癌).
- 统计分析,包括皮尔森相关性和威尔科克森等级和值测试,比较膀体积测量 (VCBCT与VHD5) 和差异.
主要成果:
- 在VCBCT和VHD5之间观察到强烈的相关性,无论是在优化前 (r=0.75) 还是在优化后 (r=0.73).
- 平均绝对膀体积差异从30.67毫升 (SD 51.40毫升) 降至5.03毫升 (SD 26.02毫升).
- 绝对体积差异VCBCT-VHD5的数据显示,优化后的数据显著减少 (P<0.001).
结论:
- 在接受盆腔放射治疗的患者中,多步工作流的优化显著提高了膀体积的一致性.
- 优化减少了差异的标准偏差和CBCT和扫描仪测量之间的绝对差异.
- 这些改善对接受放射治疗的前列腺癌,宫癌和直肠癌患者有好处.
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