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牙周炎的唾液微生物群加剧了由肠道微生物群诱导的巨细胞衍生的CXCL3引起的结肠炎

Jun Qian¹, Qing Tao^2,3, Yue Shen¹

¹Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology, Nanjing University, Nanjing, China.

|December 10, 2025

概括

牙周炎的唾液微生物群通过改变肠道细菌和增加巨细胞的CXCL3分泌来恶化结肠炎. 像Lactobacillus rhamnosus GG这样的益生菌可以帮助管理这种情况.

科学领域:

微生物学微生物学
免疫学免疫学免疫学
胃肠病学胃肠病学

背景情况:

口腔肠轴在结肠炎的发展中起着至关重要的作用.
唾液中的口腔细菌可以影响肠道微生物群和结肠炎,但机制尚不清楚.

研究的目的:

研究肠道微生物群在唾液微生物群影响的结肠炎中的作用和机制.
探索牙周炎唾液微生物群 (PSM) 如何影响大肠炎.

主要方法:

结肠炎严重程度与牙周炎唾液微生物群 (PSM) 与健康的唾液微生物群 (HSM) 的比较.
对肠道微生物群组成和关键介质的分析,如C-X-C动机化学因子连接体3 (CXCL3).
研究了Lactobacillus rhamnosus GG作为潜在的治疗干预措施的影响.

主要成果:

与HSM相比,PSM显著加剧了结肠炎,这种效应被抗生素逆转,表明有病原性肠道微生物群.
PSM导致肠道病原体 (例如大肠杆菌) 和脂多糖的增加,通过CXCL3.3促进大肠炎.
由PSM衍生的肠道微生物群在巨细胞中调节了CXCL3,这通过中性粒细胞化学反应和M2b类巨细胞极化促进了大肠炎.

结论:

肠道微生物群是PSM恶化的结肠炎的关键因素,由巨细胞激活和CXCL3分泌介导.
这项研究阐明了肠道微生物群,巨细胞和大肠炎中的化学因子之间的相互作用.
研究结果提供了关于口腔疾病如何系统地影响远端器官的见解.

关键词:

牛乳杆菌拉姆诺索斯 GG 在C-X-C基因基因基因接体3中,C-X-C基因基因基因接体3是C-X-C基因基因接体.大肠炎是什么意思我们的肠道微生物群.免疫系统的免疫系统.炎症性肠病是一种炎症性肠病.巨细胞是一个巨细胞.牙周病是指牙周病的发生.益生菌是一种益生菌.这是唾液的唾液.

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