耳病的管理:随机对照试验的系统审查和元分析
Salman Hussain1, Justine Philteos2, Hugh Kim2
1Department of Otolaryngology - Head and Neck Surgery, University of Ottawa, Ottawa, Canada.
概括
局部疗法在消灭耳菌病 (耳部真菌感染) 方面显示出超过70%的疗效. 克洛特里马是一种常见的治疗方法,副作用通常是轻微的. 需要进一步的研究才能得出最终的结论.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 菌类学 菌类学是指菌类学.
- 传染性疾病 传染性疾病
背景情况:
- 耳菌,一种耳朵的真菌感染,缺乏普遍同意的最有效的治疗方法.
- 对于临床实践来说,确定常见的自菌病治疗方法的疗效和安全性至关重要.
研究的目的:
- 评估经常用于根除土菌病的常用药物的有效性和安全性.
- 通过元分析来比较各种治疗方案的疗效.
主要方法:
- 在PubMed,Scopus,Web of Science和Cochrane数据库中进行了系统的文献搜索.
- 包括15项随机对照试验 (RCT),涉及2309名患有自菌病的成年患者.
- 对克洛特里马,米可纳和可纳进行了元分析和子组元分析.
主要成果:
- 在所有局部疗法中,整体奥托米科斯根除率为73.6%.
- 完全根除率有很大的差异,从29.0%到98.3%不等.
- 副作用不常见,主要包括耳痛,和灼热感.
结论:
- 局部疗法可以实现70%以上的完全根除奥托米科斯.
- 克洛特里马是一种经常使用和有效的治疗选择.
- 用标准化方案进行精心设计的研究是必要的,以确认发现并评估耳毒性.
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