中性粒细胞与HDL比率与全谱血糖失调之间的关联:来自中东地区大型人口研究的见解
Abdulaziz M Almuqrin1, Abdulrahman F Alrezaihi2, Ali A Aljasser2
1Chair of Medical and Molecular Genetics Research, Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh 12372, Saudi Arabia.
Healthcare (Basel, Switzerland)
|December 11, 2025
概括
中性粒细胞与HDL胆固醇的比率 (NHR) 与高血糖失调的风险有关,包括禁食葡萄糖受损和高血糖. 这种炎症标志物可能有助于识别患葡萄糖失调风险的个体,特别是在资源有限的环境中.
科学领域:
- 内分泌学 在内分泌学.
- 代谢健康 代谢健康
- 炎症研究 炎症研究
背景情况:
- 慢性炎症和脂质失调是糖尿病等代谢障碍的关键驱动因素.
- 低血糖是葡萄糖失调的早期迹象,突出了炎症和脂质代谢之间的相互作用.
- 中性粒细胞与HDL胆固醇比率 (NHR) 结合了炎症和脂质标记物,但其在失糖症中的作用尚不清楚,特别是在中东人口中.
研究的目的:
- 调查中性粒细胞与HDL胆固醇比率 (NHR) 与血糖异常之间的关联,特别是禁食葡萄糖受损 (IFG) 和高血糖 (HG).
- 在沙特阿拉伯人口中评估NHR对失糖症的风险和诊断性能.
- 探索NHR,禁食葡萄糖和HbA1c水平之间的关系.
主要方法:
- 一项对沙特阿拉伯13,121名个人进行的回顾性横截面研究.
- 分析NHR与血糖状况之间的关联,根据年龄和性别对子组进行分析.
- 相关性和线性回归分析以评估NHR与禁食葡萄糖和HbA1c的关系.
主要成果:
- 升高的NHR水平与失糖症显著相关,显示从正常血糖症逐步增加到IFG和HG.
- 较高的NHR与IFG (OR=1.48) 和HG (OR=2.38) 的风险增加有关.
- 与C反应蛋白 (CRP) 相比,NHR在禁食血糖 (FBG) 的背景下显示出高血糖的优异歧视.
结论:
- 升高的NHR与失糖症显著相关,特别是高血糖症.
- NHR可以作为一种有价值的补充工具,用于识别患有失糖症风险较高的个体.
- 需要进一步的纵向研究来确认NHR在临床实践中的预测和预后效用.
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