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在固体瘤中使用RNA测序精确的RET融合检测覆盖范围不平衡分析

Ivan Gaziev1, Anna Khristichenko2, Daniil Luppov1

  • 1Institute for Personalized Oncology, Biomedical Science & Technology Park, FSAEI HE I.M. Sechenov First Moscow State Medical University of MOH of Russia (Sechenovskiy University), 119991 Moscow, Russia.

International journal of molecular sciences
|December 11, 2025
PubMed
概括

这项研究引入了一种新的方法,用于检测通过RNA-sequencing (RNA-seq) 异构体覆盖不平衡的转移过程中REarranged (RET) 基因融合. 这种方法实现了100%的准确性,改善了向癌症治疗的识别.

关键词:
在RET重新安排的过程中.有关RNA测序的RNA测序复原原瘤基因 (RET) 是一种复原原瘤基因.临床瘤学临床瘤学融合基因瘤基因的融合接收器氨酸激酶受体瘤分子诊断 瘤分子诊断

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RNA-seq

RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
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