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GAT1突变的计算分析:分子动力学和结合性自由能量计算的功能后果

Muhammad Yasir1, Jinyoung Park1, Eun-Taek Han2

  • 1Department of Pharmacology, Kangwon National University School of Medicine, Chuncheon 24341, Republic of Korea.

International journal of molecular sciences
|December 11, 2025
PubMed
概括

在GABA载体1 (GAT1) 突变影响抑制神经传递. 计算分析揭示了特定突变如何破坏GAT1的稳定,影响其功能,并可能导致神经系统疾病.

关键词:
在GAT1中,GAT1是GAT1的组成部分.在GAT1突变中.是一种.gmx_MMPBSASA 这是一个很好的例子.分子动力学模拟模拟提亚加巴因 (Tiagabine) 是一种药物.

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