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乳腺癌的最小残留疾病:瘤微环境相互作用,检测方法和治疗方法

Nigel P Murray¹, Socrates Aedo²

¹Consultant Haematologist Hospital de Carabineros de Chile, Santiago 7770199, Chile.

International journal of molecular sciences

|December 11, 2025

概括

乳腺癌的最小残留疾病可以导致晚期复发. 向瘤微环境,而不仅仅是癌细胞,可以防止转移并延长休眠期.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
癌症生物学癌症生物学

背景情况:

乳腺癌复发可能发生在辅助治疗几年后.
最小残留性疾病 (MRD) 包括治疗后传播的微观癌细胞.
这些细胞存在于复杂的瘤微环境 (TME) 中.

研究的目的:

通过针对TME,审查预防转移性乳腺癌的策略.
探索TME在癌细胞休眠和复发中的作用.
突出最近影响TME以减少转移风险的进展.

主要方法:

关于最小残留疾病和瘤微环境的当前文献的综述.
分析癌细胞和TME组件之间的动态相互作用.
检查针对TME的治疗方法.

主要成果:

脑脊髓炎,包括肌体细胞和免疫细胞,显著影响复发风险.
在TME内部的相互作用是动态的,并影响疾病的进展.
准TME为预防转移和延长休眠期提供了新的途径.

结论:

影响瘤微环境是预防转移性乳腺癌的一个有希望的策略.
治疗策略应考虑TME在癌细胞存活和休眠中的作用.
调节TME可能会降低晚期复发的风险,并延长患者的生存时间.

关键词:

乳腺癌乳腺癌乳腺癌最少残留疾病的最小残留疾病.这是一个复发的复发.瘤微环境是一个微环境.

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