运动和COPD的表观遗传调节:当前的证据和潜在的机制途径
Yuanming Zhong1, Jianhua Xu1, Xia Chen1
1School of Physical Education and Sport Sciences, Fujian Normal University, Fuzhou 350117, China.
International journal of molecular sciences
|December 11, 2025
概括
运动可以通过改变表观遗传调节剂来改善慢性阻塞性肺病 (COPD). 本综述探讨了不同运动类型如何影响COPD中的DNA甲基化,基因素修饰和非编码RNA.
科学领域:
- 肺部医学 肺部医学
- 分子生物学分子生物学
- 运动生理学 运动生理学
背景情况:
- 慢性阻塞性肺病 (COPD) 是一个重要的全球健康问题,治疗有效性有限,无法阻止病变的进展.
- 诸如DNA甲基化和非编码RNA等表观遗传机制在COPD病变发生过程中起着关键作用.
- 运动对于肺部康复至关重要,改善COPD症状和运动能力.
研究的目的:
- 审查目前关于COPD运动诱导表观遗传变化的研究结果.
- 通过表观遗传学探索运动对COPD相关途径的影响的生物学可信性.
- 识别知识上的差距,并建议未来的研究方向.
主要方法:
- 对COPD运动和表观遗传学的临床和临床前研究的审查.
- 对有氧训练,抵抗运动和高强度间歇训练效应的分析.
- 讨论表观遗传修饰,包括DNA甲基化,基因素标记和非编码RNAs.
主要成果:
- 运动与DNA甲基化,基因组修饰和COPD非编码RNA表达的变化有关.
- 这些表观遗传变化可能会影响COPD相关的路径,如抗氧化剂反应和炎症.
- 有氧,阻力和高强度间歇训练显示出潜在的表观遗传效应.
结论:
- 表观遗传修饰可能会调解COPD运动的一些益处.
- 需要进一步的研究来了解组织特异性,时间动态和因果关系.
- 对运动的表观遗传反应可能是COPD的潜在生物标志物或治疗点.
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