形虫附录中的与年龄相关的转录基因变化
Damir Quien1,2, Jelena Korac-Prlic3, Katarina Vilović4,5
1Department of Surgery, University Hospital of Split, Spinčićeva ulica 1, 21000 Split, Croatia.
International journal of molecular sciences
|December 11, 2025
概括
衰老的虫尾显示了淋巴卵泡减少和神经元完整性,反映了肠道衰老过程,如氧化应激和炎症. 这表明尾可以模拟肠道衰老机制.
科学领域:
- 胃肠病学 胃肠病学
- 衰老研究研究 衰老研究
- 分子生物学分子生物学
背景情况:
- 肠道衰老涉及结构,功能和微生物变化,影响健康.
- 富含淋巴组织和微生物群的虫状尾可能反映了肠道衰老.
研究的目的:
- 在儿科,成人和老年人群中调查虫状尾的组织学和基因表达变化.
- 为了确定尾老化是否反映肠道老化过程.
主要方法:
- 对20个形态正常的尾样本进行了组织学分析.
- RNA测序以识别成年人与老年人样本中差异表达的基因和途径.
主要成果:
- 陈旧的样本显示淋巴卵泡减少和纤维消灭.
- 在成年人和老年人群体之间确定了1004个不同表达的基因.
- 上调的途径包括氧化应激和屏障维护;下调的途径涉及神经元完整性.
- 像CLDN2,MUC2和GDF15这样的基因随着年龄的增长呈现出渐进的变化.
结论:
- 尾老化表现出淋巴组织和神经元完整性的减少,类似于肠道老化.
- 附录可以作为一个有价值的模型来研究肠道衰老,氧化应激,炎症和神经元损失.
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