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Updated: Jan 9, 2026

Mouse Model of Metabolic Dysfunction-Associated Steatotic Liver Disease with Fibrosis
06:26

Mouse Model of Metabolic Dysfunction-Associated Steatotic Liver Disease with Fibrosis

Published on: July 18, 2025

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在MASLD代谢功能障碍中ChREBP-PPARα-FGF21轴的作用

Karina Mireya Palacios Girón1, Zamira Helena Hernandez Nazara2, Montserrat Maldonado-González3

  • 1Programa de Doctorado en Ciencias en Biología Molecular en Medicina, Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara C.P. 44340, Mexico.

International journal of molecular sciences
|December 11, 2025
PubMed
概括

代谢功能障碍相关的性肝病 (MASLD) 涉及像FGF21这样的关键基因. 这项研究揭示了FGF21可能在特定患者群体中作为能量平衡受损的生物标志物.

关键词:
碳水化合物反应元素结合蛋白 (ChREBP)纤维细胞生长因子21 (FGF21)类似MLX相互作用蛋白 (MLXIPL) 的MLX与代谢功能障碍相关的脂肪性肝病 (MASLD)过氧体增殖器激活受体阿尔法 (PPARA)

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