一项关于氧化应激标志物与艾滋病毒感染者功能之间潜在病理联系的试点研究
Joel Choshi1, Haskly Mokoena1, Helen C Steel2
1Department of Physiology and Environmental Health, University of Limpopo, Sovenga 0727, South Africa.
International journal of molecular sciences
|December 11, 2025
概括
在接受抗逆转录病毒疗法 (ART) 的艾滋病毒感染者 (PLWH) 中,氧化应激标志物,如甲 (MDA) 的水平升高. 更高的超氧化物脱酶 (SOD) 活性独立地预测了在ART上的PLWH中更好的功能.
科学领域:
- 生物医学科学 生物医学科学
- 免疫学 免疫学 免疫学
- 腎臟病學 (nephrology) 是一種醫學.
背景情况:
- 人类免疫缺陷病毒 (HIV) 感染及其用抗逆转录病毒疗法 (ART) 治疗与并发症有关.
- 氧化压力与艾滋病毒的发病和并发性疾病的发展有关,包括功能障碍.
- 氧化应激在艾滋病毒感染者 (PLWH) 功能障碍中的确切作用需要进一步阐明.
研究的目的:
- 为了研究氧化应激标志物与在ART治疗的PLWH,非ART治疗的PLWH和HIV阴性个体中的功能之间的关联.
- 探索不同艾滋病毒状况组的特定氧化应激生物标志物 (MDA,SOD,TAC) 和功能 (eGFRcystC) 之间的关系.
主要方法:
- 涉及80名接受ART治疗的PLWH,27名不接受ART治疗的PLWH和44名非艾滋病毒感染者 (PNLWH) 的横截面研究.
- 血清中马隆迪化物 (MDA),超氧化解突变酶 (SOD) 和总抗氧化能力 (TAC) 被测量为氧化应激标志物.
- 评估功能使用基于cystatin C的估计膜过率 (eGFRcystC).
主要成果:
- 与没有ART和PNLWH的PLWH相比,在ART中的PLWH表现出明显更高的MDA水平.
- 在治疗轻度功能障碍的PLWH中,SOD活性明显低于正常功能患者.
- 较高的SOD活性独立预测了在ART的PLWH中更好的功能 (调整后β=2.26,p=0.042),而MDA显示没有独立的关联.
结论:
- 在PLWH的早期功能下降期间,氧化损伤和潜在的抗氧化防御功能受损可能存在.
- 超氧化物失调酶 (SOD) 可能在接受ART的PLWH中维持脏健康方面发挥关键作用.
- 需要对更大的队列进行进一步的纵向研究来证实这些发现并澄清这些关系.
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