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在雌性老鼠的抵抗训练期间,Arthrospira platensis通过调节机电联接和氧化回路来保护子宫功能

Bárbara Cavalcanti Barros¹, Anderson Fellyp Avelino Diniz^1,2, Francisco Fernandes Lacerda-Júnior¹

¹Postgraduate Program in Natural and Synthetic Products Bioactive/Health Sciences Center, Federal University of Paraiba, João Pessoa 58051-900, Brazil.

International journal of molecular sciences

|December 11, 2025

概括

补充Arthrospira platensis (Spirulina) 可以保护子宫功能免受运动引起的压力. 这项研究表明,螺旋藻增强了氧化信号传递,减少了氧化应激,在力量训练期间保持了光滑肌肉生理.

科学领域:

生殖生物学生殖生物学
营养学科学营养学科学
运动生理学运动生理学

背景情况:

藻类衍生的生物活性物是对生理压力的有前途的营养药.
亚瑟斯皮拉 (Spirulina) 具有抗氧化和抗炎性质.
渐进式力量训练 (PST) 可以通过氧化应激诱导子宫功能障碍.

研究的目的:

为了调查是否Arthrospira platensis补充剂可以防止PST诱导的子宫功能障碍.
阐明A. platensis的保护作用背后的分子机制.

主要方法:

在Wistar大鼠中进行了为期八周的跳水PST协议.
使用特定途径抑制剂对子宫收缩反应的评估.
对子宫和卵巢组织的组织学评估.

主要成果:

PST增加了子宫收缩性和肌体厚度,与氧化应激和NO,COX,NADPH氧化酶激活有关.
补充A. platensis减弱了PST引起的变化.
补充剂增强了NO信号,刺激了放松性前列腺素,并减少了超氧化物生产.

结论:

补充Arthrospira platensis可以在高强度阻力训练下保持子宫光滑肌肉生理.
A. platensis 显示出作为女性生殖健康的营养药的潜力.
分子机制涉及NO,前列腺素和氧化应激通路的调节.

关键词:

螺旋藻是指螺旋藻中的一种.藻类是一种藻类.氧化应激是一种氧化应激.渐进式力量训练是指逐步进行力量训练.顺滑肌肉的收缩性顺滑肌肉的收缩性这是子宫,子宫.

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