遗传多态性和对外植入炎的倾向:系统性审查
Filomena Salazar1, María Belén Alvarez1, Marta Relvas1
1UNIPRO, Oral Pathology and Rehabilitation Research Unit, University Institute of Health Sciences (IUCS-CESPU), 4585-116 Gandra, Portugal.
International journal of molecular sciences
|December 11, 2025
概括
遗传变异会影响患上围植入炎的风险,围植入炎是一种影响牙植入物的炎症性疾病. 识别特定的遗传标记可能有助于预测易感性和个性化治疗这种常见的植入物并发症.
科学领域:
- 牙科植入物学 牙科植入物学
- 遗传学 是一个遗传学.
- 免疫学 免疫学 免疫学
背景情况:
- 周植入炎是一种影响牙植入物寿命的重大炎症状况.
- 它的多因素性质包括潜在的遗传倾向.
- 了解遗传关联对于管理周植入炎风险至关重要.
研究的目的:
- 系统地审查和评估遗传多态性对周植入炎风险的贡献.
- 为了确定与增加对围植入炎的易感性相关的特定遗传变异.
主要方法:
- 在PubMed中进行系统的文献搜索,直到2025年,遵守PICO和PRISMA指南.
- 包括过去十年的英语临床试验和观察性研究.
- 两个审稿人的独立数据提取和定性偏差风险评估.
主要成果:
- 23项研究符合纳入标准,分析了炎症,骨代谢和免疫调节基因中的多态性.
- 发现IL-1β +3954 C/T,ET-1和IL-1β,MMP-8 rs11225395,MMP8 (-799 C/T) 和CD14 rs2569190.0与增加的周植入炎风险存在一致的关联.
- 对TNF-α -308 G/A的结果在不同人群中不一致.
结论:
- 遗传倾向在周植入炎的发展中发挥着潜在的作用.
- 识别遗传生物标志物可能可以预测易感性.
- 基于遗传特征,可以制定个性化周植入炎管理策略.
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