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对TAS1R2跨膜域激活的分子动力学见解

Yongcheng Lu1,2, Xinyi Ma1,2, Ziyue Meng1,2

  • 1Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, Bouvé College of Health Sciences, Northeastern University, Boston, MA 02115, USA.

International journal of molecular sciences
|December 11, 2025
PubMed
概括

甜味受体 (STR) 通过TAS1R2/TAS1R3异构体起作用. 分子动力学模拟揭示了由激动剂和对抗剂诱导的独特结构变化,揭示了对味觉受体激活机制的新见解.

关键词:
G-蛋白结合受体 (GPCR) 是一种模拟MDMD的模拟形状的变化 形状的变化蛋白质 - 配体相互作用受体激活受体的激活方式甜味受体是一种甜味的受体.

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