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在老年瘤微环境中驱动转移性进展的分子机制

Sudhir Kumar¹, Jagdish Chand², Preeti Sharma³

¹Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA.

International journal of molecular sciences

|December 11, 2025

概括

衰老通过瘤微环境 (TME) 促进癌症转移. 关键因素包括细胞衰老,慢性炎症和免疫力下降,创造了适合癌症在老年人中扩散的条件.

科学领域:

在瘤学瘤学.
老年学是指老年学的学科.
免疫学免疫学免疫学

背景情况:

转移是癌症死亡的主要原因,衰老显著影响其进展.
全球预期寿命的增加导致老年人癌症发病率和复杂性增加.
了解衰老的瘤微环境 (TME) 是解决老年人群转移的关键.

研究的目的:

审查老年TME促进癌症转移的分子和细胞机制.
探索衰老特征的相互作用,如衰老,炎症和免疫衰退,以促进转移性发育.
讨论针对与年龄相关的转移性因素的新兴治疗策略.

主要方法:

关于老年TME分子和细胞机制的文献综述.
对衰老特征的分析:细胞衰老,炎症,免疫衰老,ECM重塑和血管生成.
检查分子通路 (例如TGF-β,STAT3,MAPK) 和衰老驱动因素 (例如端粒缩短,DNA损伤).

主要成果:

累积的衰老细胞分泌SASP,重塑ECM并激活前转移性途径 (EMT,入侵).
慢性炎症和免疫衰退会产生一种免疫抑制的TME,有助于免疫逃避.
血管和代谢变化,包括缺氧,支持侵袭性癌症生长和转移.
分子衰老的特征有助于遗传不稳定性,促进了前转移性肌瘤.

结论:

老年TME呈现出一个复杂的环境,显著增强癌症转移.
治疗策略,如老化剂,抗炎药和免疫调节,显示出有希望的结果.
特定年龄的模型和精准医学对于改善老年癌症患者的治疗结果至关重要.

关键词:

老化的老化衰老的老化衰老的标志衰老的标志癌症癌症癌症癌症癌症细胞衰老细胞衰老免疫功能障碍免疫功能障碍转移转移转移转移分子机制的分子机制.瘤微环境是一个微环境.

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