微塑料对小鼠AOM/DSS诱发性结肠炎相关结肠直肠癌的发展的影响
Natalia Zolotova1, Maria Kirillova1, Dzhuliia Dzhalilova1,2
1Department of Immunomorphology of Inflammation, Avtsyn Research Institute of Human Morphology of Federal State Budgetary Scientific Institution "Petrovsky National Research Centre of Surgery", Moscow 117418, Russia.
International journal of molecular sciences
|December 11, 2025
概括
微塑料 (MPs) 暴露在小鼠中加剧了结肠炎相关结肠直肠癌 (CAC) 的发展. 国会议员通过增加炎症和破坏肠道屏障来促进瘤生长,这表明CAC的潜在环境风险因素.
科学领域:
- 环境健康 环境健康
- 胃肠病学 胃肠病学
- 毒理学 毒理学 毒理学
背景情况:
- 越来越多的证据将微塑料 (MP) 与不良健康影响联系起来.
- 在癌症发生,特别是结直肠癌中,MPs的作用需要进一步研究.
研究的目的:
- 评估MP对小鼠模型中结肠炎相关结肠直肠癌 (CAC) 的发展的影响.
主要方法:
- 成年雄性C56BL/6小鼠被用于建立AOM/DSS诱导的CAC模型.
- 一组接受了5μm聚烯MPs (1.48 mg/kg/天) 在饮用水中12周;对照组接受了未经处理的水.
主要成果:
- 暴露于MPs的小鼠表现出瘤结节的增加,瘤患病率的增加,炎症透的增强,以及结肠中杯体和肠内分泌细胞含量的改变.
- 没有观察到MPs对特定基因表达 (克劳丁,肌,巴克斯,Mki67) 或血清细胞因子水平 (TNFα,IL-1β,IL-6,IL-10) 的显著影响.
结论:
- 微塑料通过加剧肠道炎症和损害上皮屏障,促进小鼠的CAC发育.
- 国会议员可能充当环境辅助因素,导致结直肠癌的风险.
关键词:
克劳丁斯·克劳丁斯·克劳丁斯结肠炎相关的结肠直肠癌细胞因子 细胞因子肠内分泌细胞 肠内分泌细胞玻璃杯细胞 玻璃杯细胞这是一种炎症炎症炎症炎症.微塑料微塑料的使用粘膜 粘膜 粘膜 粘膜瘤的结节是瘤的结节.更多相关视频
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