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Updated: Jan 7, 2026

Direct Restart of a Replication Fork Stalled by a Head-On RNA Polymerase
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Published on: April 29, 2010

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在头部转录复制冲突期间,DNA聚合酶,RNA聚合酶和RNase H1之间的相互作用

Nadezhda A Timofeyeva1, Ekaterina I Tsoi1, Darya S Novopashina1

  • 1Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.

International journal of molecular sciences
|December 11, 2025
PubMed
概括

这项研究揭示了在转录复制冲突 (TRC) 期间RNA聚合酶 (RNAP) 和DNA聚合酶相互作用如何影响DNA复制叉的稳定性. RNase H1 (RH1) 可以通过将RNAP从特定的停滞复合体中取代来解决TRC.

关键词:
DNA聚合酶是一种DNA聚合酶.这是一个R环.这种RNA聚合酶是RNA聚合酶.在RNase H1中.酶活性的酶活性.酶动力学 酶动力学转录-复制冲突发生.

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